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Research

Chronic Diseases and Contraceptive Use

Hormonal methods of contraception may affect a chronic disease and may be less desirable options in some cases. However, barrier methods or natural family planning -- which have high typical failure rates -- may pose risks of unintended, dangerous pregnancy in women with certain medical conditions.

Network: Winter 1999, Vol. 19, No. 2

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 Breast cancer
 Contraceptive choices
Note: Any contraceptive method is appropriate for women with undiagnosed breast mass, benign breast disease or a family history of breast cancer.
  •  Copper IUD is a good contraceptive choice.
  • According to the World Health Organization (WHO), combined oral contraceptives (OCs), combined injectables, DMPA, NET-EN and Norplant are contraindicated. Progestin-only pills and LNg-IUDs are usually undesirable to initiate.
Endometrial, ovarian, cervical cancer
 Contraceptive choices
Note: OCs reduce risk of developing endometrial and ovarian cancer.
  • In general, treatment of these cancers causes sterility.
  • If treatment is not available and contraception is needed, OCs, progestin-only pills, combined injectables, DMPA, NET-EN and Norplant are good choices.
  • Use of Copper or LNg-IUDs should not be initiated, but may be continued if the cancer develops during use. 
 Cardiovascular diseases
 Contraceptive choices
Note: Smoking increases the risk of cardiovascular disease at all ages. For women 35 years or older who are light smokers, OCs are usually undesirable. For women 35 years or older who are heavy smokers (more than 20 cigarettes daily), OCs should not be used and combined injectables are usually undesirable.
Deep venous thrombosis/ pulmonary embolism (history of or current)
  • Progestin-only pills, DMPA, NET-EN, Norplant and both Copper and LNg-IUDs are good choices.
  • Sterilization should be delayed until the condition is treated and resolved.
  • OCs or combined injectables are contraindicated.
Hypertension

Past (excluding hypertension in pregnancy) or mild (140-159/90-99 mm Hg)

  • Progestin-only pills, Norplant and both Copper and LNg-IUDs are good choices.
  • OCs and combined injectables are usually undesirable methods or are second choices (methods for which health benefits outweigh potential risks). DMPA and NET-EN are second choices.
  • For female sterilization, hypertension increases general anesthesia risks. Hypertension does not affect the safety of vasectomy.
Hypertension

Moderate (160-179/100-109 mm Hg)

  • Progestin-only pills, Norplant and both Copper and LNg-IUDs are good choices. DMPA and NET-EN are second choices.
  • Combined injectables are usually undesirable. OCs are generally contraindicated. If moderate hypertension develops during use, OCs should be discontinued.
  • For female sterilization, hypertension increases general anesthesia risks.
Hypertension

Severe (180/110 mm Hg or greater) or vascular disease

  • Copper IUD is a good choice. Progestin-only pills, Norplant and LNg-IUDs are second choices. DMPA and NET-EN are usually undesirable methods.
  • OCs and combined injectables are contraindicated.
  • For female sterilization, hypertension increases general anesthesia risks.
Diabetes
 Contraceptive choices
Diabetes

Without vascular disease

  • All methods can be used.
  • Female and male sterilization can be performed but with extra precautions to anticipate possible hypoglycemia or ketoacidosis, and the increased risk of postoperative wound infections.
Diabetes

With vascular disease or diabetes for more than 20 years

  • The Copper IUD is a good contraceptive choice. Progestin-only pills, Norplant and LNg-IUDs are second choices.
  • OCs and combined injectables either are contraindicated or are usually undesirable methods of choice.
  • DMPA and NET-EN are usually undesirable choices.
  • For female sterilization, refer client to a center with additional medical support for potential complications. Male sterilization can be performed but with extra preparation and precaution since diabetes increases the risk of postoperative infection.
Liver disease
 Contraceptive choices
.
  • The Copper IUD is a good choice for women with active viral hepatitis, cirrhosis or liver tumors.
  • Progestin-only pills, DMPA, NET-EN, Norplant and the LNg-IUD are methods of last choice for women with active viral hepatitis, severe cirrhosis or liver tumors.
  • OCs are contraindicated in women with active viral hepatitis, severe cirrhosis, or any kind of liver tumor, and are a last choice for women with mild cirrhosis.
Neurological
 Contraceptive choices
Epilepsy
  • DMPA and the Copper or LNg-IUDs are good contraceptive choices.
  • For women taking anticonvulsants (except valproic acid), the efficacy of OCs, progestin-only pills, combined injectables and Norplant may be reduced.
  • Female sterilization can be performed with extra precautions.
Headache: severe recurrent, with focal neurological symptoms (includes migraine)
  • Copper and LNg-IUDs, and sterilization are good choices.
  • OCs and combined injectables are not recommended.
  • Progestin-only pills, DMPA, NET-EN or Norplant are usually undesirable methods if this type of headache develops during their use.
Sickle cell
 Contraceptive choices
.
  • Progestin-only methods (pills, injectables, Norplant or LNg-IUD) are good choices.
  • WHO recommends combined hormonal methods (pills and injectables) and Copper IUD as second choices (methods for which health benefits outweigh potential risks).
Note: Because the antibiotics rifampicin and griseofulvin may reduce the efficacy of hormonal contraceptive methods, OCs, progestin-only pills, combined injectables and Norplant are usually undesirable choices for women taking these drugs.

Sources:
World Health Organization. Improving Access to Quality Care in Family Planning. Medical Eligibility Criteria for Contraceptive Use. Geneva: World Health Organization,1996; U.S. Agency for International Development. Recommendations for Updating Selected Practices in Contraceptive Use: Volumes I/II. Washington: U.S. Agency for International Development, 1994/1997.

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