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Reproductive Health

Progestin-Only Injectables (POIs) FAQ

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What are progestin-only injectables?
Progestin-only injectable contraceptives (e.g., Depo Provera, Noristerat) contain no estrogen. To prevent pregnancy, a shot is given every two or three months, depending on the type of injectable.
How do they work? (mechanism of action)
  • Prevent ovulation
  • Thicken cervical mucus (make it hard for sperm to penetrate)
  • Change endometrium (make it thin and probably not suitable for implantation)
Who can use progestin-only injectables?
Women of any reproductive age or parity who:
  • Want to use this method of contraception
  • Have no contraindications
Who should not use progestin-only injectables?
Women who have the following conditions (contraindications):
  • Pregnancy
  • Unexplained vaginal bleeding (before evaluation)
  • Current breast cancer
(For more information, see WHO eligibility criteria.)
Advantages
  • Highly effective
  • Reversible (with delay in return to fertility)
  • Easy to use
  • Do not interfere with intercourse
  • Private
  • Do not affect breastfeeding
  • Have beneficial non-contraceptive effects (protection from endometrial cancer, ectopic pregnancy and symptomatic PID). May reduce sickle crises in women with sickle cell anemia
  • May prevent seizures in epileptics
Disadvantages
  • Delay return to fertility (by average of nine months after the last injection)
  • Have common side effects
  • No protection from STIs/HIV
Possible side effects
  • Irregular menstrual bleeding/spotting
  • Amenorrhea
  • Weight gain
  • Headaches
  • Nausea
Provide follow-up and counseling for:
  • Any client concerns
  • Common side effects, especially irregular bleeding/spotting or amenorrhea
  • Importance of timely injection
Dispelling myths regarding progestin-only injectables
Injectables DO NOT:
  • Cause birth defects
  • Cause permanent infertility